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Genes and Common Diseases presents an up-to-date view of the role of genetics in modern medicine, reflecting the strengths and limitations of a genetic perspective. The current shift in emphasis from the study of rare single gene disorders to common diseases brings genetics into every aspect of modern medicine, from infectious diseases to therapeutics. However, it is unclear whether this increasingly genetic focus will prove useful in the face of major environmental influences in many common diseases. The book takes a hard and self-critical look at what can and cannot be achieved using a genetic approach and what is known about genetic and environmental mechanisms in a variety of common diseases. It seeks to clarify the goals of human genetic research by providing state-of-the art insights into known molecular mechanisms underlying common disease processes while at the same time providing a realistic overview of the expected genetic and physiological complexity.

1 Genes and their expression 

? Dirk-Jan Kleinjan 

2 Epigenetic modification of chromatin 

? Donncha Dunican, Sari Pennings and Richard Meehan 

3 Population genetics and disease 

? Donald F. Conrad and Jonathan K. Pritchard 

4 Mapping common disease genes 

? Naomi R. Wray and Peter M. Visscher 

5 Population diversity, genomes and disease 

? Gianpiero L. Cavalleri and David B. Goldstein 

6 Study design in mapping complex disease traits 

? Harry Campbell and Igor Rudan 

7 Diseases of protein misfolding 

? Christopher M. Dobson 

8 Aging and disease 

? Thomas T. Perls 

9 The MHC paradigm: genetic variation and complex

disease 

? Adrian P. Kelly and John Trowsdale 

10?Lessons from single gene disorders 

? Nicholas D. Hastie 

11?Environment and disease 

? A.?J. McMichael and K.?B.?G. Dear 

12?Contemporary ethico-legal issues in genetics 

? Renate Gertz, Shawn Harmon and Geoffrey Pradella 

Section 2: Common Medical Disorders

13?Developmental disorders 

? Stephen P. Robertson and Andrew O.?M. Wilkie 

14?Genes, environment and cancer 

? D. Timothy Bishop 

15?The polygenic basis of breast cancer 

? Paul D.?P. Pharoah and Bruce A.?J. Ponder 

16?TP53: A master gene in normal and tumor suppression 

? Pierre Hainaut 

17?Genetics of colorectal cancer 

? Susan M. Farrington and Malcolm G. Dunlop 

18?Genetics of autoimmune disease 

? John I. Bell and Lars Fugger 

19?Susceptibility to infectious diseases 

? Andrew J. Walley and Adrian V.?S. Hill 

20?Inflammatory bowel diseases 

? Jean-Pierre Hugot 

21?Genetic anemias 

? W.?G. Wood and D.?R. Higgs 

22?Genetics of chronic disease: obesity 

? I. Sadaf Farooqi and Stephen O'Rahilly 

23?Type 2 diabetes mellitus 

? Mark I. McCarthy 

24?Genetics of coronary heart disease 

? Rossi Naoumova, Stuart A. Cook, Paul Cook and Timothy J.

Aitman 

25?Genetics of hypertension 

? B. Keavney and M. Lathrop 

26?Obstructive pulmonary disease 

? Bipen D. Patel and David A. Lomas

27?Skeletal disorders 

? Robert A. Colbert 

28?The genetics of common skin diseases 

? Jonathan Rees 

29?Molecular genetics of Alzheimer's disease and other adult-onset

dementias 

? P.?H. St George-Hyslop 

30?Major psychiatric disorders in adult life 

? Amanda Elkin, Sridevi Kalidindi, Kopal Tandon and Peter

McGuffin 

31?Speech and language disorders 

? Gabrielle Barnby and Anthony J. Monaco 

32?Common forms of visual handicap 

? Alan Wright 

33?Genetic and environmental influences on hearing

impairment 

? Karen P. Steel 

34?Pharmacogenomics: clinical applications 

? Gillian Smith, Mark Chamberlain and C. Roland Wolf 

Index

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　　Genes and Common Diseases presents an up-to-date view of the

role of genetics in modern medicine, reflecting the strengths and

limitations of a genetic perspective. The current shift in emphasis

from the study of rare single gene disorders to common diseases

brings genetics into every aspect of modern medicine, from

infectious diseases to therapeutics. However, it is unclear whether

this increasingly genetic focus will prove useful in the face of

major environmental influences in many common diseases. The book

takes a hard and self-critical look at what can and cannot be

achieved using a genetic approach and what is known about genetic

and environmental mechanisms in a variety of common diseases. It

seeks to clarify the goals of human genetic research by providing

state-of-the art insights into known molecular mechanisms

underlying common disease processes while at the same time

providing a realistic overview of the expected genetic and

physiological complexity.

　　? Written by leading experts in genetics at a level that the

practising clinician can understand ? Introductory sections explain

the basics of genetics and molecular medicine, setting the scene

for the disease chapters in the following section ? Wide range of

clinical disorders covered and clear illustrations which help

explain complex genetic concepts

书籍介绍

Genes and Common Diseases presents an up-to-date view of the role of genetics in modern medicine, reflecting the strengths and limitations of a genetic perspective. The current shift in emphasis from the study of rare single gene disorders to common diseases brings genetics into every aspect of modern medicine, from infectious diseases to therapeutics. However, it is unclear whether this increasingly genetic focus will prove useful in the face of major environmental influences in many common diseases. The book takes a hard and self-critical look at what can and cannot be achieved using a genetic approach and what is known about genetic and environmental mechanisms in a variety of common diseases. It seeks to clarify the goals of human genetic research by providing state-of-the art insights into known molecular mechanisms underlying common disease processes while at the same time providing a realistic overview of the expected genetic and physiological complexity.