Genetics, Health Care and Public Policy基因、卫生保健和公共政策：公共卫生基因导论 pdf snb 115盘 kindle 在线 下载 pmlz mobi

Genetics，Health Care and Public Policy is an introduction to the new discipline of public health genetics。It brings together the insights of genetic and molecular science as a means of protecting and improving the health of the population。Its scope is wide and requires an understanding of genetics，epidemiology，public health and the principles of ethics，law and the social sciences。This book sets out the basic principles of public health genetics for a wide audience from those providing health care to those involved in establishing policy。The emphasis throughout the text is on providing an accessible introduction to the field。The content moves from the basic concepts，including definitions and history，through chapters on genetics，genetic technology，epidemiology，genetics in medicine，genetics in health services，ethical，legal and social implications，to the implications for health policy。It provides one-stop，introductory coverage of this rapidly developing and multidisciplinary field。

Foreword

Acknowledgements

1 Introduction

The definition of public health genetics

Genetic and environmental factors as determinants of health

Genetic disease，complex disease and the combined effects of

genetic and environmental factors

The emergence and development of public health genetics

Advances in epidemiology and its application to public health

The rise of genetic epidemiology

The growth of genetic science

The impetus for public health genetics

Community genetics

Attitudes to public health genetics

An international public health genetics network：the Bellagio initiative

About this book

Further reading and resources

Principles of public health

The emergence of public health genetics

The human genome project and‘genomic medicine’

Community genetics

Current developments in public health genetics

Genomics and global health

2 Genetic science and technology

Basic molecular genetics

Genes and the genome

Chromosomas

　　The‘central dogma’：DNA makes RNA makes Drotein

　　Gene structure and expression in more detail

　The complexity of the genetic programme

　Genetic variation：mutation and polymorphism

　Cell division and the maintenance of the genome

　Miosis and recombination：the formation 0f sex cells

　Inheritance patterns

　Genes and disease

　Mendelian(‘single—gene’)diseases

　 Mitochondrial disorders

　 Chromosomal disorders

　 Diseases caused by disorders in epigenetic mechanisms

　 Mendelian subsets of common diseases

　MultifactoriaI disease

　Cancer

　Some complexities of the relationship between genes and djsease

　　Penetrance

　Inherited and new mutations

　Genetic heterogeneity

　Variable expressivity

　Genetic technology

　 Cutting and joining pieces of DNA

　Separating pieces of DNA in a mixture

　Detecting specific sequences：hybridisation

　 Fluorescent in situ hybridisation(FISHl

　 DNA cloning and clone libraries

　 The polymerase chain reaction

　 DNA sequencing

　 DNA microarrays

　 Markers and maps

　The human genome project

　　Mapping human genetic variation：SNPs and haplotypes

　The post—genome challenge

　　Identifying genes and studying gene function

　　Proteomics

　　Comparative genomics

　　Bioinformatics

　　Systems biology

　　Epidemiological and biomedical informatics

　　……

3 Fundamentals of genetic epidemiology

4 Genetics in medicine

5 Genetics in health services

6 Ethical，legal and social implications of genetics

7 Policy implications

Index

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书籍介绍

Genetics, Health Care and Public Policy is an introduction to the new discipline of public health genetics. It brings together the insights of genetic and molecular science as a means of protecting and improving the health of the population. This book sets out the basic principles of public health genetics for a wide audience of readers from those providing health care to those involved in establishing health policy. It provides one-stop introductory coverage of this rapidly developing and multidisciplinary field.